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The risk of atherosclerotic vascular disease is increased both in subjects with non-insulin-dependent diabetes mellitus(NIDDM)and in those with impaired glucose tolerance compared with nondiabetic subjects.Common carotid and carotid bifurcation IMTs were greater in the NIDDM group than in control subjects(P<.05 to.01).In NIDDM patients,the mean carotid IMT correlated with postglucose 1-hour plasma insulin(r=.305,P=.01,adjusted for age and sex),serum LDL triglyceride(r=.237,P<.05),and apolipoprotein B concentrations(r=.263,P<.05).Carotid IMT was greater in NIDDM patients than in control subjects.The main determinants of IMT in NIDDM patients were related to both postglucose insulin levels and abnormal lipoprotein profiles characteristic of NIDDM and insulin resistance syndrome.Treatment of these factors is likely to reduce the atherosclerotic burden in NIDDM. |
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